|
KMID : 0869620080250010037
|
|
Journal of Korean Society of Hospital Pharmacists
2008 Volume.25 No. 1 p.37 ~ p.45
|
|
|
|
|
Kim Mi-Kyung
Son Ho-Yyun
Kwon Mi-Kyung
Jung Hyun-Mi
Kim Yoon-Suk
Jin Young-Dae
Kim Ae-Ran
Lee Hyung-Kyung
|
|
|
Abstract
|
|
|
|
Peak inspiratory flow rate(PIFR) through dry powder inhalers(DPIs) is important for effective drug delivery to the airways. PIFR above 60 L/min is generally accepted to be the optimal flows for DPIs, while PIFR below 30L/min is insufficient for DPIs. But few studies have evaluated PIFR through the DPIs in Korea. So we investigated improvement of PIFR after training inspiratory performance at the first visit. At the second visit, we again investigated PIFR through the Diskus and Turbuhaler by PIF-meter(IN-check TM Dial). In addition, we analyzed the effect of age and forced expiratory volume in 1 second(FEV1%) on PIFR. We studied 117 patients (mean age 62 years, 44% female, 45 chronic obstructive pulmonary disease(COPD) patients, 59 Asthma patients, FEV1 69%, using Diskus 64 patients) at first visit. Overall, 22 patients(19%) showed weak inhalation through DPIs. Post-counseling, only three patients did not achieve PIFR > at least 30L/min(p<0.05). At second visit, study in 27 patients(mean age 62 years, 59% female, 7 COPD patients, 16 Asthma patients, FEV1 75%, using Diskus 16 patients, mean PIFR 61 L/min) showed mean PIFR improvement. And we found that PIFR negatively correlated with age and weak positively correlated with FEV1%. In conclusion, this study demonstrates that patients with inadequately weak inhalation for using DPIs could improve of PIFR after training inspiratory performance and PIFR correlated with age and FEV1%
|
|
|
KEYWORD
|
|
|
PIFR, DPIs, FEV1%, PIF-meter(IN-check TM Dial), improvement
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|